Oral metronidazole has been described to potenti-ate the anticoagulant impact of coumarin and warfarin resulting in a prolongation of prothrombin time. The effect of topical metronida-zole on prothrombin time will not be recognised.
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Utilization of cimetidine with oral metronidazole may possibly extend the 50 percent-lifetime and reduce plasma clearance of metronidazole.
There was no experience to this point with using METROGEL® (metronidazole topical gel) Topical Gel in Expecting clients. Metronidazole crosses the placental barrier and enters the fetal circulation quickly.
METROGEL-VAGINAL is the intravaginal dosage form of the artificial antibacterial agent, metronidazole, USP in a concentration of 0.75%. Metronidazole is actually a member from the imidazole class of antibacterial brokers and is assessed therapeutically being an antiprotozoal and antibacterial agent.
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In past clinical trials submitted for accredited labeling of METROGEL-VAGINAL the subsequent was also claimed:
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Slowly but surely push the plunger right until it stops to deposit gel into vagina after which withdraw the applicator.
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WARNINGS If major discomfort develops from using this medication, discontinue use and speak to your physician.
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Should you be going through an allergic response, Get hold of the unexpected emergency services or go straight to your local A&E.
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